Received Mar 6; Accepted Oct Production and hosting by Elsevier B. All rights reserved. This article has been cited by other articles in PMC. The mechanical properties of the tablets were improved as concentration of Kollidon SR or other polymers increased. The marketed product was found to release
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Received Mar 6; Accepted Oct Production and hosting by Elsevier B. All rights reserved. This article has been cited by other articles in PMC. The mechanical properties of the tablets were improved as concentration of Kollidon SR or other polymers increased.
The marketed product was found to release Drug release from all previous formulations is best described to be controlled by more than one kinetic mechanism of release. Introduction Bronchial asthma, a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyper-responsiveness bronchospasm , and an underlying inflammation Renz, Albuterol Sulphate, the most widely prescribed bronchodilator in the United Kingdom on the control of asthma Dennis et al.
As a result of the quick absorption and short half-life, it is administered orally 3—4 times a day. Due to these properties, it will be more effective to deliver this drug at a controlled but reduced input rate rather than as an oral bolus dose from a conventional immediate release dosage form.
Many different systems are used to improve the clinical efficacy of drugs having short half-lives as well as to increase patient compliance by controlling the rate of drug delivery Claxton et al. These formulations are designed to deliver drugs at a predetermined rate over a wide range of conditions and durations of therapeutic treatments Reddy et al. One of the most commonly used methods of developing controlled release formulations for therapeutic agents is to include them in matrix tablets prepared by direct compression as they are easy to manufacture and their preparation involves few processing variables Corti et al.
Using a suitable rate controlling polymer, the matrix can be tableted by direct compression or conventional wet granulation method. Swellable matrix systems with anomalous release kinetics are suitable solutions for drug release control intended for oral administration Colombo et al.
The resulting release mechanism depends on the relative importance of tablet relaxation and drug diffusion rate and by adjusting these two rates; it is possible simultaneously to control the release mechanism and the release rate Colombo et al.
From an economical point of view the production of sustained release tablets by direct compression is of a great promise. In this respect Kollidon SR, a convincing excipient is expected to be easily applicable for a broad selection of different drugs Siepmann et al.
Kollidon SR has a unique character of maintaining tablets geometric shape until the end of dissolution test, this is mainly due to its major component; the water insoluble polyvinyl acetate, while the minor water soluble part; polyvinylpyrrolidone, is responsible for pore formation causing diffusion controlled release mechanism Draganoiu et al.
Another polymer of great promise in matrix tablets formulations is Carbopol that is an oral Pharmaceutical grade of the carbomers. It is a synthetic, high molecular weight crosslinked polymer of acrylic acid, readily hydrates, absorbs water and swells Khan and Jiabi, In addition, its hydrophilic nature and highly crosslinked structure make it a potential candidate for use in controlled drug delivery systems Parojcic et al. Materials and methods 2. All other chemicals used were of high analytical grade.
Methods 2. Preparation of tablets All tablet formulations with different drug to polymer ratios were prepared by direct compression technique Formulations I—XIII, Table 1.
Effect of Kollidon® SR on the release of Albuterol Sulphate from matrix tablets
Corresponding author. Received Dec 28; Accepted Feb Sustained release or controlled release products have became popular for the oral administration of such drugs because they give more consistent blood levels. Sustained release or controlled release with zero order release kinetics maintains plasma concentration of such types of drugs at constant level for better effect.
Technical Information: Kollidon SR
Read more Solid Dispersions In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation. Read more Direct Compression Direct compression DC is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form.