INTRAVENTRICULAR AMIKACIN DOSE FILETYPE PDF

Staphylococcus aureus and Nocardia are the only gram-positive bacteria strongly affected by amikacin. Boxed Warnings: Amikacin may cause serious neurotoxicity manifested by vestibular toxicity and permanent bilateral auditory ototoxicity especially in patients on long-term and high doses of the medicine. High-frequency deafness occurs first and can be diagnosed with audiometry. Vestibular dysfunction may present with vertigo.

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Selected References These references are in PubMed. This may not be the complete list of references from this article. Suceptibility of aminoglycoside-resistant gram-negative bacilli to amikacin: delineation of individual resistance patterns.

J Infect Dis. Cerebrospinal fluid penetration of amikacin. Antimicrob Agents Chemother. Kanamycin and gentamicin treatment of neonatal sepsis and meningitis. Susceptibility of recently isolated bacteria to amikacin in vitro: comparisons with four other aminoglycoside antibiotics. Aminoglycoside therapy of gram-negative bacillary meningitis. N Engl J Med. Problems with neonatal meningitis. J Antimicrob Chemother.

Amikacin: a rapid and sensitive radioimmunoassay. Pharmacologic evaluation of gentamicin in newborn infants. Intraventricular gentamicin therapy in gram-negative bacillary meningitis of infancy. An analysis of external ventricular drainage as a treatment for infected shunts. Childs Brain. Intraventricular and parenteral gentamicin therapy for ventriculitis in children.

Am J Dis Child. Infections of cerebrospinal fluid shunts: epidemiology, clinical manifestations, and therapy. Amikacin therapy of gram-negative bacteremia and meningitis.

Treatment in diseases due to multiple resistant bacilli. Arch Intern Med. Comparison of four aminoglycoside antibiotics in the therapy of experimental E. J Lab Clin Med. Intraventricular use of aminoglycosides in the treatment of gram-negative bacillary meningitis: conflicting views. Amikacin concentration in the cerebrospinal fluid of children with acute bacterial meningitis.

J Int Med Res. The pharmacokinetics and efficacy of an aminoglycoside administered into the cerebral ventricles in neonates: implications for further evaluation of this route of therapy in meningitis.

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Mezigar J Spinal Disord Tech. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. However, cases of true infection that have no CSF white blood cells have been reported. Management of meningitis due to antibiotic-resistant Acinetobacter species Residual shunt infection in a program aimed at its prevention. Diagn Microbiol Infect Dis. Two reports of carbapenem use for Pseudomonas aeruginosa have described low rates of development of carbapenem resistance during therapy with extended infusions of the antibiotic. Current recommendations from the Infectious Diseases Society of America IDSA regarding empirical antimicrobial therapy for postneurosurgical meningitis, are for intravenous vancomycin plus either cefepime, ceftazidime, or meropenem.

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INTRAVENTRICULAR AMIKACIN DOSE FILETYPE PDF

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