Staphylococcus aureus and Nocardia are the only gram-positive bacteria strongly affected by amikacin. Boxed Warnings: Amikacin may cause serious neurotoxicity manifested by vestibular toxicity and permanent bilateral auditory ototoxicity especially in patients on long-term and high doses of the medicine. High-frequency deafness occurs first and can be diagnosed with audiometry. Vestibular dysfunction may present with vertigo.
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Selected References These references are in PubMed. This may not be the complete list of references from this article. Suceptibility of aminoglycoside-resistant gram-negative bacilli to amikacin: delineation of individual resistance patterns.
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Treatment in diseases due to multiple resistant bacilli. Arch Intern Med. Comparison of four aminoglycoside antibiotics in the therapy of experimental E. J Lab Clin Med. Intraventricular use of aminoglycosides in the treatment of gram-negative bacillary meningitis: conflicting views. Amikacin concentration in the cerebrospinal fluid of children with acute bacterial meningitis.
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Mezigar J Spinal Disord Tech. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. However, cases of true infection that have no CSF white blood cells have been reported. Management of meningitis due to antibiotic-resistant Acinetobacter species Residual shunt infection in a program aimed at its prevention. Diagn Microbiol Infect Dis. Two reports of carbapenem use for Pseudomonas aeruginosa have described low rates of development of carbapenem resistance during therapy with extended infusions of the antibiotic. Current recommendations from the Infectious Diseases Society of America IDSA regarding empirical antimicrobial therapy for postneurosurgical meningitis, are for intravenous vancomycin plus either cefepime, ceftazidime, or meropenem.
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